Call 413.540.1234 to
schedule an appointment
CONCERN/EAP: 413.534.2625
Billing questions? Call: 413.540.1212
CRISIS: 413.733.6661

Child Development & Parenting: Infants (0-2)
Resources
Basic Information
Infant Development: How Your Baby Grows and MaturesInfant Parenting: Keeping Your Baby Healthy and HappyInfant Safety: Keeping Your Baby SafeInfant Enrichment: Stimulating Your Baby
More InformationLatest News
Zika Babies Facing Increasing Health Problems With AgeNearby Fracking Linked to Low Birth WeightsWindow Blinds: A Silent Killer in Your HomeHealth Tip: Starting a Tooth Brushing Routine EarlyWhen a Preemie Goes Home, Dad Stresses OutState Newborn Screening Policies Cut Infant Cardiac DeathsLock Eyes With Your Baby, Synchronize Brain Waves?Newborns in Pain Might Not Show ItHealth Tip: Childproof Your HomePractice Variation in Treatment for Bronchiolitis in InfantsHealth Tip: How to Clean a Breast PumpBabies Start Connecting Words Early OnHealth Tip: Infant Medication Advice For New MomsHow to Spot the Virus That Puts Some Babies in the HospitalProlonged Breast-Feeding May Guard Against Teen EczemaVaccination Coverage High for Children Aged 19 to 35 MonthsU.S. Preemie Birth Rates Rise 2 Years in a RowDelayed Cord Clamping Not Beneficial for Preterm InfantsEven Partial Breast-Feeding for First Few Months Lowers SIDS RiskHealth Tip: Sleep Train Your BabyACAAI: Doctors Not Adhering to New Peanut GuidelinesHypothermia May Help Newborns With EncephalopathyOb/Gyns Warn Against 'Vaginal Seeding' Trend for NewbornsKids, Don't Touch the Toys at the Doctor's OfficeCDC Updates Zika Guidance for Infant CareHigher Doses of Vitamin D May Boost Preemies' Bone HealthHealth Tip: Avoid Baby Sleep PositionersHelping Preemies Avoid Unnecessary AntibioticsProtecting Preemies From Stress Might Improve Later Mental Health'Sleep Positioners' a Danger to Baby: FDAClinical Exome Sequencing Useful for Critically Ill InfantsTdap Given in Pregnancy Protects Infants From PertussisWhooping Cough Shot Works, But Many Moms-to-Be Skip It: CDCHealth Tip: Breast-feeding May Help TeethHeart-Lung Fitness Challenged in Early Full-Term BabiesHealth Tip: Is Your Baby Teething?Pediatricians Increasingly Aligned With Breastfeeding GuidelinesHigher Cigarette Taxes May Mean Fewer Infant DeathsHealth Tip: Design a Non-Toxic NurseryParents Getting Better at Using Car Seats SafelyVision Problems Common in Babies Infected With Zika'Modest at Best' Discriminatory Ability for CBC Test in InfantsDoes General Anesthesia Affect Babies' Brains?Health Tip: Avoid Juice Before Age 1Race/Ethnicity Shown to Factor Into Quality of Care in NICUHep B Vaccine Should Be Given Sooner: Pediatricians GroupSome Newborns Don't Get Heart Defect, Hearing Loss TestsAnti-Vaccine Info in Pregnancy May Delay Infant ImmunizationToo Many Babies Still Placed on Stomach to Sleep: StudyAnti-Vaccine Family Members, Friends Spur Many Moms to Delay Baby's Shots
Questions and AnswersLinks
Related Topics

Child & Adolescent Development: Overview
Childhood Mental Disorders and Illnesses
Parenting
Child Development & Parenting: Early (3-7)
Child Development & Parenting: Middle (8-11)

Characteristics of Diabetes in Infancy Explored


HealthDay News
Updated: Aug 9th 2017

new article illustration

WEDNESDAY, Aug. 9, 2017 (HealthDay News) -- Diabetes in infancy has different characteristics depending on mutation subtype, and is associated with high frequency of diabetic ketoacidosis (DKA), according to a report published online Aug. 4 in Diabetes Care.

Lisa R. Letourneau, M.P.H., R.D., from the University of Chicago, and colleagues examined diagnosis records from 88 cases with diabetes onset ≤13 months of age. The authors assessed laboratory values and sign/symptoms, and subdivided participants by similar mutation subtypes among those with a causal mutation for diabetes.

The researchers found that the most common form of infancy-onset diabetes was KCNJ11-related diabetes (37.5 percent), followed by "unknown" (likely type 1 diabetes; 21.6 percent); transient neonatal diabetes occurred in 14 percent. The median age at diagnosis of diabetes was 10.4 weeks; age at diagnosis differed significantly by mutation subtype. Diagnosis age was significantly lower in the transient diabetes group versus the permanent group (median, 15.2 versus 0.43 weeks). Polyuria, tachypnea, flu-like symptoms, tiredness/weakness, dehydration, and "not acting right" were the most commonly reported signs/symptoms. Blood glucose, pH, bicarbonate, hemoglobin A1c, and DKA were dependent on the subtype of mutation. The frequency of DKA was 66.2 percent overall, and increasing age at diagnosis correlated with increased odds of DKA (odds ratio, 1.23 per one month increase).

"Continuing to educate pediatric providers about the many ways that infants can present with diabetes may help to diagnose cases more efficiently and ultimately decrease the frequency of DKA at diagnosis," the authors write.

The study was funded by a grant from Novo Nordisk.

Abstract/Full Text