Call 413.540.1234 to
schedule an appointment
CONCERN/EAP: 413.534.2625
Billing questions? Call: 413.540.1212
CRISIS: 413.733.6661

Alzheimers Disease and other Cognitive Disorders
Resources
Basic Information
Introduction & Causes of Cognitive DisordersDementiaAlzheimer's DiseaseOther Cognitive DisordersDementia Coping Skills & Behavior ManagementTraumatic Brain Injury (TBI)Conclusion and Resources
More InformationLatest News
Can Alzheimer's Be Spread? Mouse Study Hints It's PossibleDoctors' Office Dementia Tests Are Often Wrong: StudyAlzheimer's Vaccine Shows Promise in MiceKey Strategies When Caring for a Loved One With DementiaFor Down Syndrome Adults, Death and Dementia Often Come TogetherAHA: What's the Blood Pressure Connection to Alzheimer's Disease?Could Diabetes Drugs Help Curb Alzheimer's?Hard Arteries Hard on the Aging Brain?Widely Used Antipsychotics May Not Ease Delirium in ICUCould Herpes Virus Help Cause Alzheimer's?Map of Mouse Hippocampus Could Be Weapon Against Alzheimer'sHealth Tip: 10 Signs of Alzheimer'sA-Fib Tied to Higher Odds for DementiaAlzheimer's Gene Tied to 'Chemo Brain' in Breast Cancer SurvivorsDiabetes, Dementia Can Be Deadly CombinationWhat's the Dollar Cost of Caring for a Loved One With Alzheimer's?Exercise May Delay Rare Form of Alzheimer'sAHA: Stiffening of Blood Vessels May Point to Dementia RiskU.S. Alzheimer's Cases to Nearly Triple by 2060Daytime Drowsiness a Sign of Alzheimer's?Exercise May Boost Brain Power in Alzheimer's, Mouse Study SuggestsSeverity of Alzheimer's Can Vary by SeasonHealth Tip: Help Kids Understand Alzheimer'sWith Stroke Comes Higher Dementia Risk: StudyEyes Could Be Window to Predicting Alzheimer'sDialysis Linked to Dementia in SeniorsWhen Head Injuries Make Life Too Hard, Suicide Risk May RiseMore Alzheimer's Gene Links FoundEye Disease Link to Alzheimer's SeenHow Severe Brain Injuries Might Trigger DementiaAlzheimer's Drug Trial Offers New Hope, But Uncertainty, TooGet Dizzy Upon Standing? It Could Be Sign of Dementia RiskSleeping Pills May Be Poor Choice for Dementia PatientsVirtual Reality as a Window Into DementiaThe Right Lighting Can Calm Alzheimer's PatientsCould Pot-Linked Drug Help Ease Agitation in Alzheimer's?Many Americans With Dementia Don't Know They Have It: StudyHaving More Kids Tied to Lower Odds of Alzheimer's in WomenWhy Alzheimer's May Be Tougher to Spot in WomenHow Common Is Dementia Among LGBT Seniors?Life Is Short After Dementia Diagnosis, No Matter Your AgeDoes a Woman's Childbearing History Affect Her Alzheimer's Risk?Health Tip: What's the Difference Between Delirium and Dementia?Obesity Adds to Burden of Traumatic Brain InjuryCould Aspirin Help Keep Alzheimer's Away?Scientists Spot Gene Linking Down Syndrome, Early Alzheimer'sRobots May Soon Join Ranks of Alzheimer's CaregiversCould Herpes Virus Play a Role in Alzheimer's?Health Tip: Living With Dementia"Markers" of Alzheimers Do Not Doom You to Dementia
Questions and AnswersLinksBook Reviews
Related Topics

Aging & Geriatrics
Memory Problems
Elder Care

Certain Anticholinergic Drugs Appear to Raise Dementia Risk


HealthDay News
Updated: Apr 27th 2018

new article illustration

FRIDAY, April 27, 2018 (HealthDay News) -- Use of anticholinergic drugs may be tied to a future diagnosis of dementia, according to a study published online April 25 in The BMJ.

Kathryn Richardson, Ph.D., from University of East Anglia in the United Kingdom, and colleagues estimated the association between the duration and level of exposure to different classes of anticholinergic drugs and subsequent incident dementia in 40,770 patients (aged 65 to 99 years) diagnosed with dementia between April 2006 and July 2015, and 283,933 controls without dementia.

The researchers found that 35 percent of cases and 30 percent of controls were prescribed at least one anticholinergic drug during the study period. For any anticholinergic drug with an Anticholinergic Cognitive Burden (ACB) score of 3, the adjusted odds ratio for dementia was 1.11. Increasing average ACB score increased the risk of dementia. Gastrointestinal drugs with an ACB score of 3 were not linked to dementia, but the risk of dementia increased with greater exposure for antidepressant, urological, and anti-Parkinson's drugs with an ACB score of 3. Even for exposure 15 to 20 years before a diagnosis, the results persisted.

"A robust association between some classes of anticholinergic drugs and future dementia incidence was observed," the authors write. "Future research should examine anticholinergic drug classes as opposed to anticholinergic effects intrinsically or summing scales for anticholinergic exposure."

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text
Editorial